Evaluation of chelating agents as anti-angiogenic therapy through copper chelation

…, M Sproull, S Tantama, V Venditto, S Sankineni…

Index: Camphausen, Kevin; Sproull, Mary; Tantama, Steve; Venditto, Vincent; Sankineni, Sandeep; Scott, Tamalee; Brechbiel, Martin W. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 19 p. 5133 - 5140

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Citation Number: 16

Abstract

The evaluation of several sets of polyamine donor chelating agents including a selection of novel hexadentate 1, 3, 5-cis, cis-triaminocyclohexane (tach) based derivatives were performed in an in vitro endothelial cell proliferation assay to assess their cytotoxicity and selectivity as novel anti-angiogenic agents. The selective nature of the anti-angiogenic agents for human umbilical vein endothelial cells (HUVEC) was compared to a normal ...