Enantioselective Synthesis of Tertiary and Quaternary Stereogenic Centers: Copper/Phosphoramidite??Catalyzed Allylic Alkylation with Organolithium Reagents

M Fañanás??Mastral, M Pérez, PH Bos…

Index: Fananas-Mastral, Martin; Perez, Manuel; Bos, Pieter H.; Rudolph, Alena; Harutyunyan, Syuzanna R.; Feringa, Ben L. Angewandte Chemie - International Edition, 2012 , vol. 51, # 8 p. 1922 - 1925

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Citation Number: 40

Abstract

Copper-catalyzed asymmetric allylic alkylation (AAA) has become a very powerful tool for the enantioselective construction of optically active tertiary carbon stereocenters.[1] Recently, this CÀC bond-forming reaction has also been successfully applied to the challenging enantioselective synthesis of all-carbon quaternary stereogenic centers in acyclic systems.[2] Organozinc,[3] aluminium,[4] and Grignard [5] reagents have been ...