Tetrahedron letters

Biosynthesis of tetronasin: Part 6. Preparation of structural analogues of the diketide and triketide biosynthetic precursors to tetronasin

SL Less, S Handa, K Millburn, PF Leadlay, CJ Dutton…

Index: Less, Simon L.; Handa, Sandeep; Millburn, Karen; Leadlay, Peter F.; Dutton, Christopher J.; Staunton, James Tetrahedron Letters, 1996 , vol. 37, # 20 p. 3515 - 3518

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Citation Number: 34

Abstract

The preparation of three analogues of the putative diketide biosynthetic precursor (2) and eight analogues of the putative triketide biosynthetic precursor (3) of the acyl tetronic acid ionophore tetronasin, as N-acetylcysteamine thioesters (4),(5),(6),(12),(13),(14),(15),(22),(23 ),(24) and (25) is described. Five examples are 19F-labelled; a new, enantiospecific method for the creation of a fluorinated quaternary α-centre is presented.