e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

An efficient access to both enantiomers of pipecolic acid

LA Watanabe, S Haranaka, B Jose, M Yoshida…

Index: Tetrahedron Asymmetry, , vol. 16, # 4 p. 903 - 908

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Citation Number: 36

Abstract

... Tetrahedron: Asymmetry. Volume 16, Issue 4, 21 February 2005, Pages 903–908. ... the development of many synthetic approaches involving enzymatic reactions, 14 alkylation of chiral glycine enolates, 15 derivatization of natural amino acids, 16 enantioselective reactions, 17 ...

N-acetyl-D-2-amino-6-bromohexanoic acid Structure

N-acetyl-D-2-am...

~40%

H-D-HomoPhe-OH Structure

6-bromo-2-acetamido-2-ethoxycarbonyl-hexanoic acid ethyl ester Structure

6-bromo-2-aceta...

~%

H-D-HomoPhe-OH Structure

Boc-DL-Ab6-OEt Structure

~%

H-D-HomoPhe-OH Structure

N-Boc-D-2-amino-6-bromohexanoic acid ethyl ester Structure

N-Boc-D-2-amino...

~%

H-D-HomoPhe-OH Structure

6-bromo-2-((tert-butoxycarbonyl)amino)-2-(ethoxycarbonyl)hexanoic acid Structure

6-bromo-2-((ter...

~%

H-D-HomoPhe-OH Structure

diethyl 2-(4-bromobutyl)-2-((tert-butoxycarbonyl)amino)malonate Structure

diethyl 2-(4-br...

~%

H-D-HomoPhe-OH Structure

N/A Structure

~%

H-D-HomoPhe-OH Structure

(R)-6-bromo-2-((tert-butoxycarbonyl)amino)hexanoic acid Structure

(R)-6-bromo-2-(...

~%

H-D-HomoPhe-OH Structure

N-Boc-D-2-amino-6-bromohexanoic acid Structure

N-Boc-D-2-amino...

~%

H-D-HomoPhe-OH Structure

2-acetamido-6-bromo-2-ethoxycarbonylhexanoate Structure

2-acetamido-6-b...

~%

H-D-HomoPhe-OH Structure

An efficient, asymmetric synthesis of pipecolic acid and 2-a...

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Efficient syntheses of enantioenriched (R)-pipecolic acid an...

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Synthesis of 2-piperidinecarboxylic acid derivatives as pote...

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