We have previously proposed the existence of a lipophilic cavity of the 2-amino-3-(3-hydroxy- 5-methylisoxazol-4-yl) propionic acid (AMPA) receptor recognition site capable of accommodating alkyl substituents of limited size in the 5-position of the isoxazole ring. In order to indirectly elucidate the approximate extent of this proposed cavity we have synthesized and pharmacologically characterized a number of AMPA analogues. For most ...
