Bioorganic & medicinal chemistry letters

Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer …

S Gobec, P Brožič, TL Rižner

Index: Gobec, Stanislav; Brozic, Petra; Rizner, Tea Lanisnik Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 23 p. 5170 - 5175

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Citation Number: 42

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) like indomethacin, flufenamic acid, and related compounds have been recently identified as potent inhibitors of AKR1C3. We report that some other NSAIDs (diclofenac and naproxen) also inhibit AKR1C3, with the IC50 values in the low micromolar range. In order to obtain more information about the structure– activity relationship and to identify new leads, a series of compounds designed on the ...

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