Mechanisms of trovafloxacin hepatotoxicity: studies of a model cyclopropylamine-containing system

Q Sun, R Zhu, FW Foss, TL Macdonald

Index: Sun, Qin; Zhu, Ran; Foss Jr., Frank W.; Macdonald, Timothy L. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6682 - 6686

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Citation Number: 10

Abstract

The mechanism for the hepatotoxicity of trovafloxacin remains unresolved. Trovafloxacin contains a cyclopropylamine moiety which has a potential to be oxidized to reactive intermediate (s) although other putative elements may exist. In this study, a drug model of trovafloxacin containing the cyclopropylamine substructure was synthesized. Chemical oxidation of the drug model by K3Fe (CN) 6 and NaClO revealed that both oxidants ...