Organic letters

Cross-coupling of non-activated chloroalkanes with aryl Grignard reagents in the presence of iron/N-heterocyclic carbene catalysts

SK Ghorai, M Jin, T Hatakeyama, M Nakamura

Index: Ghorai, Sujit K.; Jin, Masayoshi; Hatakeyama, Takuji; Nakamura, Masaharu Organic Letters, 2012 , vol. 14, # 4 p. 1066 - 1069

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Citation Number: 56

Abstract

An efficient and high-yielding cross-coupling reaction of various primary, secondary, and tertiary alkyl chlorides with aryl Grignard reagents was achieved by using catalytic amounts of N-heterocyclic carbene ligands and iron salts. This reaction is a simple and efficient arylation method having applicability to a wide range of industrially abundant chloroalkanes, including polychloroalkanes, which are challenging substrates under conventional cross- ...