p-Nitrobenzenesulfonyl chloride as a raw material for the manufacture of sulfanilamide preparations

…, KS Borodina, VA Zasosov, EV Van'kovich…

Index: Luk'yanov, A. V.; Onoprienko, V. S.; Borodina, K. S.; Zasosov, V. A.; Van'kovich, E. V.; et al. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 9 p. 640 - 644 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 9 p. 87 - 91

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Abstract

In the manufacture of sulfanilamide preparations the first stage is the preparation of an arylsulfanilic acid chloride. Of the various derivatives of arylsulfonyl chlorides [1] the N-acyl derivatives of sulfanilic acid are used most in industry. In the domestic pharmaceutical chemical industry N-carbomethoxysulfanilyl chloride, also known as phenylurethylansulfonyl chloride, (1%, is used exclusively. ... The process of preparing (I) is simple enough and consists of the interaction of N-carbomethoxyaniline ...