Molecules

Synthesis and biological activity of trans-tiliroside derivatives as potent anti-diabetic agents

Y Zhu, Y Zhang, Y Liu, H Chu, H Duan

Index: Zhu, Yujin; Zhang, Yanjun; Liu, Yi; Chu, Hongwan; Duan, Hongquan Molecules, 2010 , vol. 15, # 12 p. 9174 - 9183

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Citation Number: 19

Abstract

Abstract A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1 H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption- enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This ...