Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates

JT Lundquist IV, DC Harnish, CY Kim…

Index: Journal of Medicinal Chemistry, , vol. 53, # 4 p. 1774 - 1787

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Citation Number: 30

Abstract

... Journal of Medicinal Chemistry. ... Although this compound suffered from poor oral bioavailability, it served as a chemical tool to demonstrate triglyceride (TG) lowering in rats. Natural product-like libraries provided hits for Nicolaou et al. ...