Synthesis and Structure–Activity Relationship of Naphtho [1, 2-b] furan-2-carboxamide Derivatives as Melanin Concentrating Hormone Receptor 1 Antagonists

CJ Lim, JY Choi, BH Lee, KS Oh, KY Yi

Index: Lim, Chae Jo; Choi, Jun Young; Lee, Byung Ho; Oh, Kwang-Seok; Yi, Kyu Yang Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 12 p. 1239 - 1247

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Citation Number: 3

Abstract

The discovery that novel naphtho [1, 2-b] furan-2-carboxamides containing linked piperidinylphenylacetamide groups serve as melanin concentrating hormone receptor 1 (MCH-R1) antagonists is described. An extensive structure–activity relationship (SAR) study, probing members of this family that contain a variety of aryl and heteroaryl groups at C-5 of the naphtho [1, 2-b] furan-2-carboxamide skeleton and having different chain linker ...