Nucleoside analogues are important agents in the battle against some of the most serious human illnesses including cancer, parasitic infections and viral diseases.[1–3] In combating viral infections such as HIV, herpes simplex virus, and hepatitis C, nucleoside analogues are particularly indispensable and target reverse transcriptases, polymerases or other enzymes involved in DNA/RNA synthesis, replication and repair.[4–6] Most nucleoside analogue ...
