A ligand-free solid-supported system for Sonogashira couplings: applications in nucleoside chemistry

…, CC Woodroofe, CJ Lacenere, SR Quake…

Index: Garg, Neil K.; Woodroofe, Carolyn C.; Lacenere, Christopher J.; Quake, Stephen R.; Stoltz, Brian M. Chemical Communications, 2005 , # 36 p. 4551 - 4553

Full Text: HTML

Citation Number: 27

Abstract

Over the past several decades, transition metal-mediated cross-coupling reactions have emerged as powerful methods for the formation of carbon–carbon bonds. 1 Of the many cross-coupling processes, the Pd-catalyzed Sonogashira coupling of aryl or vinyl halides with terminal alkynes 2 has found high utility in modern organic chemistry, with applications ranging from natural product synthesis and pharmaceuticals to the development of organic materials (1 + 2 → 3, Fig. ...