Chemistry Letters

A Mild and Selective Cleavage of p-Methoxybenzyl Ethers by CBr4-MeOH.

JS Yadav, BVS Reddy

Index: Yadav; Reddy, B. V. Subba Chemistry Letters, 2000 , # 5 p. 566 - 567

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Citation Number: 4

Abstract

Selective protection and deprotection of hydroxyl group is an important process in multi-step synthesis of complex natural products.1 Among various hydroxyl protecting groups, the p- methoxybenzyl (PMB) ether is one of the most commonly used due to its stability towards a variety of reaction conditions and it can be removed selectively in the presence of benzyl ethers under mild conditions. Different methods are available for the selective removal of PMB group, which ...