e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Kinetics of the reaction of. beta.-methoxy-. alpha.-nitrostilbene with thiolate ions. First direct observation of the intermediate in a nucleophilic vinylic substitution
CF Bernasconi, RB Killion Jr, J Fassberg…
Index: Bernasconi, Claude F.; Killion, Robert B.; Fassberg, Julianne; Rappoport, Zvi Journal of the American Chemical Society, 1989 , vol. 111, # 17 p. 6862 - 6864
Upon mixing 4 with RS-a rapid reaction is observed, which leads to a species whose absorption spectrum is distinctly different from that of 4 and 6 (Figure 1). The similarity of this spectrum to that of thiolate ion adducts of a-nitros til bene^^ and the fact that the intermediate slowly converts to 6 constitute strong evidence that the intermediate is 5. The kinetics of intermediate formation and conversion to products were measured separately. Rates of ...