Novel trivalent anti-influenza reagent

…, Y Sakoda, M Okamatsu, H Kida, SI Nishimura

Index: Feng, Fei; Miura, Nobuaki; Isoda, Norikazu; Sakoda, Yoshihiro; Okamatsu, Masatoshi; Kida, Hiroshi; Nishimura, Shin-Ichiro Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3772 - 3776

Full Text: HTML

Citation Number: 9

Abstract

We designed and synthesized novel trivalent anti-influenza reagents. Sialyllactose was located at the terminal of each valence which aimed to block each receptor-binding site of the hemagglutinin (HA) trimer on the surface of the virus. Structural analyses were carried out with a model which was constructed with a computer simulation. A previously reported cyclic glycopeptide blocker [Ohta, T.; Miura, N.; Fujitani, N.; Nakajima, F.; Niikura, K.; ...