Microwave-assisted synthesis of sec/tert-butyl 2-arylbenzimidazoles and their unexpected antiproliferative activity towards ER negative breast cancer cells

…, NN Muttiah, W Boon Keat, S Abd. Hamid…

Index: Abdul Rahim, Aisyah Saad; Muhamad Salhimi, Salizawati; Arumugam, Natarajan; Pin, Lim Chung; Yee, Ng Shy; Muttiah, Nithya Niranjini; Keat, Wong Boon; Abd. Hamid, Shafida; Osman, Hasnah; Mat, Ishak B. Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 , vol. 28, # 6 p. 1255 - 1260

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Citation Number: 5

Abstract

A new series of N-sec/tert-butyl 2-arylbenzimidazole derivatives was synthesised in 85–96% yields within 2–3.5 min by condensing ethyl 3-amino-4-butylamino benzoate with various substituted metabisulfite adducts of benzaldehyde under focused microwave irradiation. The benzimidazole analogues were characterised using 1H NMR, 13C NMR, high resolution MS and melting points. Evaluation of antiproliferative activity of the benzimidazole analogues ...