Journal of medicinal chemistry

Specific competitive inhibition of L-asparaginyl transfer ribonucleic acid lygase by. beta.-aminoamides

TO Yellin, MR Harnden

Index: Harnden; Yellin Journal of medicinal chemistry, 1970 , vol. 13, # 6 p. 1095 - 1098

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Abstract

The introduction of the enzyme L-asparaginase (L-:~ sparagine amidohydrolase) into clinical trials has been the most dramatic development in the treatment of leukemia in recent years. The ultimate usefulness of this enzyme has yet to be determined but the initial results