A coordinated synthesis and conjugation strategy for the preparation of homogeneous glycoconjugate vaccine candidates

EJ Grayson, GJL Bernardes, JM Chalker…

Index: Grayson, Elizabeth J.; Bernardes, Goncalo J. L.; Chalker, Justin M.; Boutureira, Omar; Koeppe, Julia R.; Davis, Benjamin G. Angewandte Chemie - International Edition, 2011 , vol. 50, # 18 p. 4127 - 4132

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Citation Number: 37

Abstract

Glycoconjugates are the center of many therapeutic strategies [1–3] and carbohydrate- based vaccines in particular hold great promise.[4–8] The development of glycovaccines, however, can be hindered by the limited access offered by natural sources to homogeneous antigenic carbohydrates; efficient chemical synthesis offers an attractive route to pure samples of these carbohydrates. Furthermore, for an optimal immune response, the ...