Tetrahedron letters

Highly regioselective monoalkylation of ketones via manganese enolates prepared from manganese amides

G Cahiez, B Figadère, P Cléry

Index: Cahiez, Gerard; Figadere, Bruno; Clery, Patrick Tetrahedron Letters, 1994 , vol. 35, # 19 p. 3065 - 3068

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Citation Number: 23

Abstract

Abstract Ketones are regioselectively converted to Mn-enolates by treatment with Mn- amides such as Ph (Me) NMnCl in THF at 20 C. Mn-enolates can then be regioselectively monoalkylated in good yields. The formation of di or polyalkylated products is never observed (< 1%).