Synthesis and antimicrobial activity of 5-nitrofurfural heteryl hydrazones

LN Vostrova, MV Grenaderova, VS Nedzvetskii…

Index: Vostrova, L.N.; Grenaderova, M.V.; Nedzvetskii, V.S.; Konup, I.P.; Andreeva, E.K.; Bondar, A.E. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 5 p. 408 - 412 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 5 p. 584 - 587

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Abstract

We know from [3, 4] that the diamides of diimidazopyrazine-5, 10-dione-l, 6-dicarboxylic acid are easily broken down upon reacting with bases to the corresponding amino acids, amido esters, and diamides. In a similar manner we split compounds (1-VIII) with hydrazine hydrate to the amido hydrazides (IX-XVI) which formed hydrazones (XVII-XXIV) upon condensation with 5-nitrofurfurol.