New efficient substrates for semicarbazide-sensitive amine oxidase/VAP-1 enzyme: analysis by SARs and computational docking

F Yraola, S García-Vicente…

Index: Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6197 - 6208

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Citation Number: 31

Abstract

... Journal of Medicinal Chemistry. ... Results and Discussion. Combinatorial Chemistry. A combinatorial approach was applied to define the structural ligand requirements for new SSAO substrates. To explore the substitution ...

 Related Synthetic Route
p-Fluorobenzaldehyde oxime Structure

459-23-4

p-Fluorobenzald...

~%

4-Fluorobenzylamine Structure

140-75-0

4-Fluorobenzylamine

4-Fluorobenzaldehyde Structure

459-57-4

4-Fluorobenzaldehyde

~%

4-Fluorobenzylamine Structure

140-75-0

4-Fluorobenzylamine

2,4-dimethoxybenzaldehyde Structure

613-45-6

2,4-dimethoxybe...

~%

2,4-Dimethoxybenzylamine Structure

20781-20-8

2,4-Dimethoxybe...

p-Tolualdehyde Structure

104-87-0

p-Tolualdehyde

~%

4-Methylbenzylamine Structure

104-84-7

4-Methylbenzylamine

4-(Trifluoromethoxy)benzaldehyde Structure

659-28-9

4-(Trifluoromet...

~%

4-(Trifluoromethoxy)benzylamine Structure

93919-56-3

4-(Trifluoromet...

2-Fluorobenzaldehyde Structure

446-52-6

2-Fluorobenzaldehyde

~%

1-(2-Fluorophenyl)methanamine Structure

89-99-6

1-(2-Fluorophen...

3,5-Dimethoxybenzaldehyde Structure

7311-34-4

3,5-Dimethoxybe...

~%

3,5-Dimethoxybenzylamine Structure

34967-24-3

3,5-Dimethoxybe...

4-(Trifluoromethyl)benzaldehyde Structure

455-19-6

4-(Trifluoromet...

~%

4-(Trifluoromethyl)benzylamine Structure

3300-51-4

4-(Trifluoromet...

4-Formylbenzoic acid Structure

619-66-9

4-Formylbenzoic acid

~%

4-(Aminomethyl)benzoic acid Structure

56-91-7

4-(Aminomethyl)...


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