Heterocycles

A diversity oriented synthesis of 2, 10-dioxo-10H-1, 2, 3, 4, 4a, 5-hexahydropyridazino [3, 2-b] quinazolines

E Schuler, N Juanico, J Teixido, EL Michelotti, JI Borrell

Index: Schuler, Elisabeth; Juanico, Nacho; Teixido, Jordi; Michelotti, Enrique L.; Borrell, Jose I. Heterocycles, 2006 , vol. 67, # 1 p. 161 - 173

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Citation Number: 4

Abstract

Résumé/Abstract A parallel method for the synthesis of the title compounds is described. Thus, methyl anthranilates (5) are transformed into 2-aminobenzohydrazides (3) which were treated with 4-oxo acids (4) to afford in high yields and acceptable purity of piridazino [3, 2-b] quinazolines (1). Compounds (1) present four diversity centers (R 1, R 2, R 3, and R 4). The range of chemically acceptable substituents at each center has been evaluated. The ...