Organic letters

N-heterocyclic carbene (NHC)-catalyzed direct amidation of aldehydes with nitroso compounds

FT Wong, PK Patra, J Seayad, Y Zhang, JY Ying

Index: Fong, Tian Wong; Patra, Pranab K.; Seayad, Jayasree; Zhang, Yugen; Ying, Jackie Y. Organic Letters, 2008 , vol. 10, # 12 p. 2333 - 2336

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Citation Number: 75

Abstract

NHC-catalyzed direct amidation of aldehydes with nitroso compounds is a powerful method for the synthesis of N-arylhydroxamic acids. A variety of aryl, alkyl, alkenyl, and heterocyclic aldehydes were found to give excellent yields of the corresponding N-arylhydroxamic acids. This chemistry was also extended to the synthesis of chiral N-arylhydroxamic acids by kinetic resolution of α-branched aldehydes, a domino amidation− redox amination ...