Synthesis

An Efficient Synthesis of 2, 4-Substituted [1, 8] Naphthyridines from 3-(2-Amino-5-methylpyridin-3-yl)-1-arylprop-2-yn-1-ones

G Abbiati, A Arcadi, F Marinelli, E Rossi

Index: Abbiati, Giorgio; Arcadi, Antonio; Marinelli, Fabio; Rossi, Elisabetta Synthesis, 2002 , # 13 p. 1912 - 1916

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Citation Number: 4

Abstract

Abstract 3-(2-Amino-5-methylpyridin-3-yl)-1-arylprop-2-yn-1-ones 2, readily available through Pd-catalyzed carbonylative coupling of 5-methyl-3-[2-(trimethylsilyl) ethynyl] pyridine-2-ylamine (1) with aryl iodides in the presence of carbon monoxide, undergo a domino conjugate addition/annulation reaction to give 4-heterosubstituted 2-aryl [1, 8] naphthyridines 3 in high yields.