A clean and rapid synthesis of 5-amino and 5-alkoxycarbonylpyrazoles using montomorillonite under acid free conditions

GJ Reddy, D Latha, KS Rao

Index: Jagath Reddy; Latha; Srinivasa Rao Organic Preparations and Procedures International, 2004 , vol. 36, # 5 p. 494 - 498

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Citation Number: 11

Abstract

The synthesis of 5-aminopyrazoles 3 were carried out by refluxing P-ketonitriles (2) with hydrazines (1) in refluxing isopropanol in presence of montomorillonite. It is interesting to note that the reaction times required are dramatically reduced to less than 1 hr, compared to 6-8 hrs when the same reaction is carried out in refluxing ethanol with or without the presence of acetic acid. This method could be applied for the synthesis of a variety of 1, 3- ...