Studies of the Synthesis of Diethyl Cyclopropylphosphonate and Its Thio and Seleno Analogs

Y Zafrani, R Chen, N Ashkenazi…

Index: Zafrani, Yossi; Chen, Ravit; Ashkenazi, Nissan; Segall, Yoffi Synthetic Communications, 2008 , vol. 38, # 6 p. 848 - 857

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Abstract

Abstract Two methods for the synthesis of unsubstituted diethyl cyclopropylphosphonate are described. One method is a reaction between cyclopropylmagnesium bromide and diethyl chlorophosphite to give diethyl cyclopropylphosphonite, followed by oxidation with sodium periodate to the corresponding phosphonate. Alternatively, diethyl cyclopropylphosphonite was reacted with elemental sulfur or selenium to give the thio and seleno analogs, ...