Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1, 3, 4-oxadiazoles

…, A Ahadian, P Navabi, V Zanganeh, A Shafiee

Index: Zarghi, Afshin; Tabatabai, Sayyed A.; Faizi, Mehrdad; Ahadian, Avideh; Navabi, Parisa; Zanganeh, Vahideh; Shafiee, Abbas Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 7 p. 1863 - 1865

Full Text: HTML

Citation Number: 186

Abstract

A series of new 2-substituted-5-(2-benzyloxyphenyl)-1, 3, 4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism.