Abstract A series of 2, 3, 4, 6-tetrahydro-8, 9-dimethoxybenzo [c][2, 7] naphthyridin-5 (1H)- ones was prepared as potential anticholinergic bronchodilators. The naphthyridine ring system was constructed by cyclization of a 3-amido-4-piperidone. Alkylation with alkylaminoethyl chlorides or reductive amination of an intermediate methyl ketone yielded the final target compounds.
