e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
4-Methoxy-2, 6-dimethylbenzenesulphonyl (Mds): a new protecting group of the guanidino function in peptide synthesis
M Fujino, O Nishimura, M Wakimasu…
Index: Fujino, Masahiko; Nishimura, Osamu; Wakimasu, Mitsuhiro; Kitada, Chieko Journal of the Chemical Society, Chemical Communications, 1980 , # 14 p. 668 - 669
The 4-methoxy-2, 6-dimethylbenzenesulphonyl (Mds) group for the protectiono of the guanidino function, which is readily removed with trifluoroacetic acid–thioanisole but is resistant to hydrogenolysis or treatment with dilute hydrogen chloride, can be used in the solution synthesis of arginine-containing peptides; this protecting group was effectively used in the synthesis of substance P and two LH–RH analogues.
