Synthesis and antimicrobial activity of azasteroid-type compounds and related systems. Effect of hydrophilic and lipophilic groups on activity

K Ramalingam, LF Wong, KD Berlin…

Index: Ramalingam,K. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 664 - 669

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Citation Number: 16

Abstract

13a, R= CH,; X= I b, R= H; X= Br assays have been previously reported from our laboratory.'It is apparent from Table V that growth inhibition of B. subtilis with heterocyclic systems 6, 7, 8, and 9 is found when R is an alkyl of six carbons (6d, 7d, 8b, and 9b). The HCl salts of 9a and 9b are also slightly active against P. fluorescens. N-Glucosides 6h and 6i likewise effected growth inhibition of B. subtilis and 6i was active against P. fluorescens. ...