N6-substituted adenosine receptor agonists. Synthesis and pharmacological activity as potent antinociceptive agents

…, P Malabre, JM Teulon, F Camborde…

Index: Guengoer, Timur; Malabre, Patrice; Teulon, Jean-Marie; Camborde, Francoise; Meignen, Joelle; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4307 - 4316

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Citation Number: 26

Abstract

1 6 different amines gave the desired amides l. 13 The title compounds Sa-at were obtained by the reaction of 6-chloro ribofuranuronamide 1 with different substituted (aminoethy1) indoles (method A) and then by the removal of the isopropylidene group in acidic medium, 1 N HC1 (method B) or HCOOH (50%)(method C), as outlined in Scheme 1. To obtain compounds 5a-c, l-substituted-3-(2-aminoethyl) indoles 7a-c were reacted directly on the ...