Tetrahedron Letters

Regioselective SN Ar reactions of substituted difluorobenzene derivatives: practical synthesis of fluoroaryl ethers and substituted resorcinols

SG Ouellet, A Bernardi, R Angelaud, PD O'Shea

Index: Ouellet, Stephane G.; Bernardi, Anna; Angelaud, Remy; O'Shea, Paul D. Tetrahedron Letters, 2009 , vol. 50, # 27 p. 3776 - 3779

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Citation Number: 16

Abstract

Aryl ether functionality is a prevalent structural motif found in many natural products and in biologically active compounds. 1 In the past few decades, several new methods for the preparation of aryl-aryl 2 and aryl–alkyl ethers have been described. While significant progress has been made in the field of metal-catalyzed reaction (mostly Cu and Pd), nucleophilic aromatic substitution (S N Ar) of aryl fluorides by alkoxides remains a highly efficient and useful strategy for the ...