Tetrahedron letters

A new reagent for the mediation of amide bond formation in peptide synthesis.

R Ramage, CP Ashton, D Hopton, MJ Parrott

Index: Ramage, Robert; Ashton, Christopher P.; Hopton, David; Parrott, Maxwell J. Tetrahedron Letters, 1984 , vol. 25, # 42 p. 4825 - 4828

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Citation Number: 22

Abstract

Abstract The potential application of 1-oxo-1-chlorophospholane (5) as a novel reagent for the in situ activation of Nα-protected amino acids for use in peptide bond forming reactions has been examined. Wherever possible, 32.4 Mhz 31 P nuclear magnetic resonance (nmr) spectroscopy was employed to follow both the formation of the intermediate phospholanic- carboxylic mixed anhydride and the subsequent aminolysis reaction.