Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes …

…, SR Martin, AJ Hay, M López-Querol, FX Sureda…

Index: Kolocouris, Antonios; Spearpoint, Philip; Martin, Stephen R.; Hay, Alan J.; Lopez-Querol, Marta; Sureda, Francesc X.; Padalko, Elizaveta; Neyts, Johan; De Clercq, Erik Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6156 - 6160

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Citation Number: 25

Abstract

The new 2-alkyl-2-aminoadamantanes and analogues 4–10 were designed and synthesized by simplification of the structure of the potent anti-influenza virus A spiranic aminoadamantane heterocycles 2 and 3. The aim of the present work was to examine the effects of bulky and extended lipophilic moieties attached to amantadine 1 on binding to the M2 channel and the resulting antiviral potency. The binding affinities of the compounds to ...