Tetrahedron

Enantioselective transesterification catalysis by nanosized serine protease subtilisin Carlsberg particles in tetrahydrofuran

B Castillo, Y Delgado, G Barletta, K Griebenow

Index: Castillo, Betzaida; Delgado, Yamixa; Barletta, Gabriel; Griebenow, Kai Tetrahedron, 2010 , vol. 66, # 12 p. 2175 - 2180

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Citation Number: 3

Abstract

Enzyme catalysis in organic solvents is a powerful tool for stereo-selective synthesis but the enantioselectivity is still hard to predict. To overcome this obstacle, we employed a nanoparticulate formulation of subtilisin Carlsberg (SC) and designed a series of 14 structurally related racemic alcohols. They were employed in the model transesterification reaction with vinyl butyrate and the enantioselectivities were determined. In general, short ...