Synlett

Facile cleavage of silyl protecting groups with catalytic amounts of FeCl3

YQ Yang, JR Cui, LG Zhu, YP Sun, Y Wu

Index: Yang, Yong-Qing; Cui, Jia-Rong; Zhu, Lin-Gui; Sun, Ya-Ping; Wu, Yikang Synlett, 2006 , # 8 p. 1260 - 1262

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Citation Number: 6

Abstract

Cleavage of silyl protecting groups has been the subject of numerous investigations since the late 1970s. [1] To cope with the various functional group compatibility requirements encountered in the synthesis of diverse target molecules, many methods [2] have been developed for cleaving silyl ethers such as triethylsilyl (TES), tert-butyldimethylsilyl (TBS), triisopropylsilyl (TIPS) and tert-butyldiphenylsilyl (TBDPS). However, new low-cost, mild, and environmentally benign ...