Exploring the Structure-Activity Relationships of [1-(4-tert-Butyl-3'-hydroxy) benzhydryl-4-benzylpiperazine](SL-3111), A High-Affinity and Selective δ-Opioid Receptor …

J Alfaro-Lopez, T Okayama, K Hosohata…

Index: Alfaro-Lopez, Josue; Okayama, Toru; Hosohata, Keiko; Davis, Peg; Porreca, Frank; Yamamura, Henry I.; Hruby, Victor J. Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5359 - 5368

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Citation Number: 35

Abstract

SL-3111 [1-(4-tert-butyl-3'-hydroxy) benzhydryl-4-benzylpiperazine] is a de novo designed, high-affinity and selective nonpeptide peptidomimetic agonist of the δ-opioid receptor. In a previous report we had described the unique biological characteristics of this ligand and also a need for further structural evaluation. 6 To pursue this, we have introduced a completely different heterocyclic template (2 and 3), which, based on molecular modeling ...