A robust, streamlined approach to bosutinib monohydrate

…, C Seadeek, KP Girard, SM Guinness…

Index: Withbroe, Gregory J; Seadeek, Chris; Girard, Kevin P; Guinness, Steven M; Vanderplas, Brian C; Vaidyanathan, Rajappa Organic Process Research and Development, 2013 , vol. 17, # 3 p. 500 - 504

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Citation Number: 9

Abstract

This article describes a systematic approach used to streamline the process for the isolation of bosutinib monohydrate, a promiscuous solvate former. A thorough understanding of the complex solid form landscape was garnered, and this knowledge was used to develop a process that routinely delivered the correct solid form and excellent purity at the end of the last bond-formation step, without the need for additional recrystallization and/or solid form ...