Unsaturated heterocyclic amines as potent time-dependent inhibitors of dopamine. beta.-hydroxylase

…, RJ Broersma, LC Creemer, JR McCarthy…

Index: Bargar, Thomas M.; Broersma, Robert J.; Creemer, Lawrence C.; McCarthy, James R.; Hornsperger, Jean-Marie; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 315 - 317

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Citation Number: 36

Abstract

Dopamine@-hydroxylase (DBH; EC 1.14. 17.1), a copper-dependent monooxygenase, catalyzes the conversion of dopamine to norepinephrine in the peripheral sympathetic as well as in the central nervous systems. l The enzyme is easily inhibited by copper chelators, but these types of inhibitors lack selectivity; the most notable example is fusaric acid, which was studied in the clinic for the treatment of hyperten~ ion.~~~ Recently, a number of ...