4??(4??Guanidinobenzoyl)??2??imidazolones and Related Compounds: Phosphodiesterase Inhibitors and Novel Cardiotonics with Combined Histamine H2 Receptor …

…, S Bartel, L Will??Shahab, EG Krause

Index: Glass; Buschauer; Tenor; Bartel; Will-Shahab; Krause Archiv der Pharmazie, 1995 , vol. 328, # 10 p. 709 - 719

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Citation Number: 6

Abstract

Abstract A series of new positive inotropic agents was synthesized with the aim of combining the pharmacophores of the imidazolone-type phosphodiesterase (PDE) inhibitor enoximone and guanidine-type histamine H 2 receptor agonists such as arpromidine. All compounds are para-substituted 4-benzoyl-5-alkyl-2-imidazolones. H 2 agonism was incorporated by p- (hetero) arylalkyl substituents, in particular by an imidazolylpropyl guanidine group. In ...