Total Synthesis of the Antifungal Natural Product Mollisin

S Schwolow, H Kunz, J Rheinheimer…

Index: Schwolow, Sonja; Kunz, Horst; Rheinheimer, Joachim; Opatz, Till European Journal of Organic Chemistry, 2013 , # 29 p. 6519 - 6524

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Abstract

Abstract Mollisin, a bioactive polyketide secondary metabolite of the fungus Mollisia caesia, was synthesized in nine linear steps from commercially available 2, 6-dimethyl-γ-pyrone. A key transformation in this first total synthesis of mollisin was the ipso substitution of an ...