Organic letters

Gold (III)-mediated aldol condensations provide efficient access to nitrogen heterocycles

H Waldmann, GV Karunakar, K Kumar

Index: Waldmann, Herbert; Karunakar, Galla V.; Kumar, Kamal Organic Letters, 2008 , vol. 10, # 11 p. 2159 - 2162

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Citation Number: 48

Abstract

Polycyclic N-heterocycles form the basic frameworks of numerous natural product classes and hold a prominent role in pharmaceutical and agrochemical research.(1) In particular, quinolines and their derivatives often are endowed with biological activity including compounds with antitumor activity,(2) CysLT (LTD4) receptor antagonists(3) and HIV-1 replication inhibitors.(4) For quinoline synthesis, the Friedländer annulation(5) is widely used. It proceeds both in the presence ...