Biocatalytic preparation of bicyclo [3.2. 0] heptane derivatives

N Klempier, P Geymayer, P Stadler, K Faber…

Index: Klempier, Norbert; Geymayer, Paul; Stadler, Peter; Faber, Kurt; Griengl, Herfried Tetrahedron: Asymmetry, 1990 , vol. 1, # 2 p. 111 - 118

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Citation Number: 18

Abstract

Abstract Bicyclo [3.2. 0] hept-2-en-6-ols, central building blocks for the synthesis of chiral cyclobutane and-pentane systems, were prepared with up to> 99% ee by lipase catalysed resolution of their acetates, butyrates, or isobutyrates. Substituents at C-7 vicinal to the reaction site reduced both enantioselectivity and reaction rate, whereas variation of the acid moiety showed a smaller influence. Among the lipase tested, those from Pseudomonas sp ...