Synlett

Ligand-and base-free synthesis of 1, 3-diynes catalyzed by low loading of heterogeneous Pd/C and CuI

T Kurita, M Abe, T Maegawa, Y Monguchi, H Sajiki

Index: Kurita, Takanori; Abe, Masami; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao Synlett, 2007 , # 16 p. 2521 - 2524

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Citation Number: 28

Abstract

Abstract A facile and environmentally friendly synthetic method for a variety of symmetrical 1, 3-diyne derivatives based on the Pd/C-CuI-catalyzed homocoupling reaction of terminal alkynes has been developed. The reaction was efficiently catalyzed by the extremely low loading (0.01-0.03 mol%) of Pd/C and CuI (3 mol%) in the presence of molecular oxygen (O 2) as an oxidant without any phosphine ligands and bases.