e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Orthoamide, XXXII. Umsetzungen von tert??Butoxy??N, N, N′, N′??tetramethylmethandiamin mit NH??und CH??aciden Verbindungen

W Kantlehner, F Wagner…

Index: Kantlehner, Willi; Wagner, Fritz; Bredereck, Hellmut Liebigs Annalen der Chemie, 1980 , # 3 p. 344 - 357

Full Text: HTML

Citation Number: 14

Abstract

Abstract tert-Butoxy-N, N, N′, N′-tetramethylmethandiamin (1) reagiert mit N-Formylglycin- ethylester (2) und mit N-Formyl-β-alanin-ethylester (9) zu den Aminomethylenverbindungen 3 bzw. 10. Glycinethylester wird sowohl durch 1 als auch durch Dimethylaminoformaldehyd- dimethylacetal (5) an der NH 2-Gruppe zu 6 aminomethyleniert. Ebenso wie 3 setzt sich auch 6 mit 1 zum Amidin 4 um. N-Monosubstituierte Formamide werden durch 1 in ...

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

3-Dimethylamino-2-(formylaminomethyl)acrylsaeure-ethylester Structure

3-Dimethylamino...

~0%

Ethyl 3-(dimethylamino)acrylate Structure

Ethyl 3-(dimeth...

Dimethylamine Structure

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

Ethyl glycinate Structure

Ethyl glycinate

~0%

ethyl N-((dimethylamino)methylene)glycinate Structure

ethyl N-((dimet...

Dimethylamine Structure

Detail

N-FORMYL-BETA-ALANINE ETHYL ESTER Structure

N-FORMYL-BETA-A...

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

Ethyl 3-(dimethylamino)acrylate Structure

Ethyl 3-(dimeth...

Dimethylamine Structure

Detail

N-FORMYL-BETA-ALANINE ETHYL ESTER Structure

N-FORMYL-BETA-A...

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

3-Dimethylamino-2-(formylaminomethyl)acrylsaeure-ethylester Structure

3-Dimethylamino...

Dimethylamine Structure

Detail

N,N-Dimethylformamide dimethyl acetal Structure

N,N-Dimethylfor...

Ethyl glycinate Structure

Ethyl glycinate

~0%

ethyl N-((dimethylamino)methylene)glycinate Structure

ethyl N-((dimet...

Dimethylamine Structure

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

Ethyl glycinate Structure

Ethyl glycinate

~0%

3-Dimethylamino-2-(dimethylaminomethylenamino)acrylsaeure-ethylester Structure

3-Dimethylamino...

Dimethylamine Structure

Detail

N-Formylglycine ethyl ester Structure

N-Formylglycine...

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

3-Dimethylamino-2-(dimethylaminomethylenamino)acrylsaeure-ethylester Structure

3-Dimethylamino...

Dimethylamine Structure

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

3-Dimethylamino-2-(formylamino)acrylsaeure-ethylester Structure

3-Dimethylamino...

~0%

3-Dimethylamino-2-(dimethylaminomethylenamino)acrylsaeure-ethylester Structure

3-Dimethylamino...

Dimethylamine Structure

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

Ethyl isocyanoacetate Structure

Ethyl isocyanoa...

~0%

3-Dimethylamino-2-isocyanacrylsaeure-ethylester Structure

3-Dimethylamino...

Dimethylamine Structure

Detail

N-Formylglycine ethyl ester Structure

N-Formylglycine...

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

3-Dimethylamino-2-(formylamino)acrylsaeure-ethylester Structure

3-Dimethylamino...

Dimethylamine Structure

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

Formamide,N-(phenylmethyl)- Structure

Formamide,N-(ph...

~57%

N'-benzyl-N,N-dimethylmethanimidamide Structure

N'-benzyl-N,N-d...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

N/A Structure

~0%

N2-(2-Dimethylamino-1-phenylvinyl)-N1,N1-dimethylformamidin Structure

N2-(2-Dimethyla...

tert-Butanol Structure

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

3-Dimethylamino-2-(formylaminomethyl)acrylsaeure-ethylester Structure

3-Dimethylamino...

~0%

Ethyl 3-(dimethylamino)acrylate Structure

Ethyl 3-(dimeth...

Dimethylamine Structure

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

Ethyl glycinate Structure

Ethyl glycinate

~0%

ethyl N-((dimethylamino)methylene)glycinate Structure

ethyl N-((dimet...

Dimethylamine Structure

Detail

N-methylformamide Structure

N-methylformamide

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

N1,N1,N2-Trimethylformamidine Structure

N1,N1,N2-Trimet...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Detail

N-FORMYL-BETA-ALANINE ETHYL ESTER Structure

N-FORMYL-BETA-A...

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

Ethyl 3-(dimethylamino)acrylate Structure

Ethyl 3-(dimeth...

Dimethylamine Structure

Detail

N-FORMYL-BETA-ALANINE ETHYL ESTER Structure

N-FORMYL-BETA-A...

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

3-Dimethylamino-2-(formylaminomethyl)acrylsaeure-ethylester Structure

3-Dimethylamino...

Dimethylamine Structure

Detail

N-Ethylformamide Structure

N-Ethylformamide

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

N'-ethyl-N,N-dimethylmethanimidamide Structure

N'-ethyl-N,N-di...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Detail

N,N-Dimethylformamide dimethyl acetal Structure

N,N-Dimethylfor...

Ethyl glycinate Structure

Ethyl glycinate

~0%

ethyl N-((dimethylamino)methylene)glycinate Structure

ethyl N-((dimet...

Dimethylamine Structure

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

Ethyl glycinate Structure

Ethyl glycinate

~0%

3-Dimethylamino-2-(dimethylaminomethylenamino)acrylsaeure-ethylester Structure

3-Dimethylamino...

Dimethylamine Structure

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

Formamide, N-phenyl- Structure

Formamide, N-phenyl-

~0%

Methanimidamide,N,N-dimethyl-N'-phenyl- Structure

Methanimidamide...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

3-Dimethylamino-2-(formylamino)acrylsaeure-ethylester Structure

3-Dimethylamino...

~0%

3-Dimethylamino-2-(dimethylaminomethylenamino)acrylsaeure-ethylester Structure

3-Dimethylamino...

Dimethylamine Structure

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

Formamide, N-phenyl- Structure

Formamide, N-phenyl-

~55%

Methanimidamide,N,N-dimethyl-N'-phenyl- Structure

Methanimidamide...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Detail

N-N-Propylformamide Structure

N-N-Propylformamide

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

N2-n-propyl-N1,N1-dimethylformamidine Structure

N2-n-propyl-N1,...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

Formamide,N-(phenylmethyl)- Structure

Formamide,N-(ph...

~0%

N'-benzyl-N,N-dimethylmethanimidamide Structure

N'-benzyl-N,N-d...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Detail

N-Formylglycine ethyl ester Structure

N-Formylglycine...

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

3-Dimethylamino-2-(dimethylaminomethylenamino)acrylsaeure-ethylester Structure

3-Dimethylamino...

Dimethylamine Structure

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

Ethyl isocyanoacetate Structure

Ethyl isocyanoa...

~0%

3-Dimethylamino-2-isocyanacrylsaeure-ethylester Structure

3-Dimethylamino...

Dimethylamine Structure

Detail

N-Formylglycine ethyl ester Structure

N-Formylglycine...

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

3-Dimethylamino-2-(formylamino)acrylsaeure-ethylester Structure

3-Dimethylamino...

Dimethylamine Structure

Detail

N-methylformamide Structure

N-methylformamide

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

N1,N1,N2-Trimethylformamidine Structure

N1,N1,N2-Trimet...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Detail

N-N-Propylformamide Structure

N-N-Propylformamide

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

N2-n-propyl-N1,N1-dimethylformamidine Structure

N2-n-propyl-N1,...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Detail

N-Ethylformamide Structure

N-Ethylformamide

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

~0%

N'-ethyl-N,N-dimethylmethanimidamide Structure

N'-ethyl-N,N-di...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

Formamide,N-(phenylmethyl)- Structure

Formamide,N-(ph...

~0%

N'-benzyl-N,N-dimethylmethanimidamide Structure

N'-benzyl-N,N-d...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Detail

tert-Butoxy bis(dimethylamino)methane Structure

tert-Butoxy bis...

Formamide, N-phenyl- Structure

Formamide, N-phenyl-

~0%

Methanimidamide,N,N-dimethyl-N'-phenyl- Structure

Methanimidamide...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Detail

Acid-Base studies in gaseous systems. II. The anomalous base...

[Journal of the American Chemical Society, , vol. 66, p. 435 - 442]