The Journal of Organic Chemistry

Chiral organosilicon compounds in asymmetric synthesis of chiral 1, 3-diols

TH Chan, KT Nwe

Index: Chan, T. H.; Nwe, K. T. Journal of Organic Chemistry, 1992 , vol. 57, # 23 p. 6107 - 6111

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Citation Number: 55

Abstract

Chiral 1, 3-dioh can be prepared in high enantiomeric purity (> 99% ee) from the reactions of the chiral silylcarbanion 2 with epoxides followed by oxidative cleavage of the carbonailicon bond with hydrogen peroxide. The absolute configurations of some of the chiral 1, 3-diols were determined by circular dichroism (CD).