Dipeptidyl peptidase-4 inhibitor with β-amino amide scaffold: Synthesis, SAR and biological evaluation

HJ Kim, WY Kwak, JP Min, SY Sung, HD Kim…

Index: Kim, Heung Jae; Kwak, Woo Young; Min, Jong Pil; Sung, Si Young; Kim, Ha Dong; Kim, Mi Kyung; Kim, Hae Sun; Park, Kyung Jin; Son, Moon Ho; Kim, Soon Hoe; Lee, Bong Jin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5545 - 5549

Full Text: HTML

Citation Number: 6

Abstract

Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. Several series of β-amino amide containing piperazine derivatives have been prepared and evaluated as a inhibitor of DPP4. Finally compound 5m was selected for further evaluation.