The Journal of Organic Chemistry

Base-catalyzed reaction of nitriles with alcohols. A convenient route to imidates and amidine salts

FC Schaefer, GA Peters

Index: Schaefer,F.C.; Peters,G.A. Journal of Organic Chemistry, 1961 , vol. 26, p. 412 - 418

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Citation Number: 189

Abstract

The base-catalyzed reaction of nitriles with alcohols to form imidates has been established as an attractive synthetic method which is useful for a wide variety of electronegatively substituted aliphatic and aromatic nitriles. This reaction is used as the basis for a convenient procedure for the preparation of amidine salts.